I wouldn't say never, but it's going to be much further in the future than we can imagine. We might have outposts on the Moon and Mars just like we have in low earth orbit to do some scientific research. Otherwise, it's going to be mostly robots that do the exploring in our solar system and nearby solar systems. I suppose we could someday get a giant O'Neil cylinder and push it to Alpha Centuri after we send robotic probes to make sure there is a habitable planet. But we are talking generation ships. If we want to send physical bodies, we might do some cryogenics or even better just upload your mind to a computer and 3d print a new body when you get there. All of that is possible sometime in the future but it raises the question, why?